About the author

first_imgAbout the author Jen Rankine // @CensoredPixel Slightly obsessed with anything Internet related, you’ll often find Jen in every nook and cranny she can possibly wiggle her way into. If she’s not on social media, you’ll often find her trying to frame a nice shot of something that looks slightly strange, cross-stitching, failing miserably at a game or trying to find the best burger available. Oh, cool. So which countries can I use this in?Anywhere which is included in the European Economic Area or the EEA for short. This can include places like Iceland or Norway, but some providers are offering free roaming to places outside the EEA to make their services look even better. I’m going outside the EU. Does this apply to me?Unless stated by your phone provider, this new regulation doesn’t cover you and could end up costing you a pretty penny if you don’t check this before hand. Some companies will provide special deals or packages if you’re going outside the EU so check to see what’s out there. I really like speaking to my partner/kid/friend/cat on the phone when I’m away. Does this mean I can call for free?Nope. The expensive connection charge has been dropped but the cost of the calls themselves will still be there and they’re totally free to charge whatever they want when it comes to that part.So now you can travel and show off your adventure to your hearts content without being terrified of that bill landing in your emails. Sounds ~perfect~ Need more mobile travel tips? Click on this It’s been a long time coming but a brand new shiny regulation banning roaming charges comes into force today. Basically it means you no longer get hefty bills when travelling in the EU because you’ve updated Instagram which naturally means more cash for snacks and fun stuff. Win/win. So, what does that actually mean? Basically this:EU citizens travelling within the EU won’t be charged any more than they would be at home for sending texts, phone calls or using their data.Are all phone companies offering this?Yes. It’s an EU Regulation so they have no choice but to ditch these expensive roaming charges. That being said, there will be a few differences when it comes to what each provider is offering if you exceed your normal limits. This can be a stinger and might cost you a small fortune so it’s best to check this one out before hopping on that plane. Also bear in mind that fair usage policies tend to apply to most providers so it’s probably not wise to use that data to download a film. Skyscanner is the world’s travel search engine, helping your money go further on flights, hotels and car hire.ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map Related10 ways to cut your smartphone roaming costs abroadAs of 1 July, using a mobile in Europe will cost less, but roaming costs can still be high – here’s 10 tips for keeping your charges in check.Brexit: Travelling to the EU with a UK passportThere could be some important changes coming for UK citizens travelling to Europe. Here’s what we know so far to help you be prepared. Have you checked your passport? First things first – make sure you check your passport is still valid. That’s because in the event of a no-deal Brexit,…11 money-saving smartphone holiday secretsDon’t get stung with a big bill – check our 11 top tips for how to save on smartphone costs on your holidays.last_img read more

Common opioidbased painkillers increase harmful side effects in people with dementia

first_img Source:http://www.exeter.ac.uk/news/featurednews/title_671935_en.html Jul 24 2018Commonly-prescribed opioid-based painkillers led to harmful side effects tripling in people with dementia.Researchers from the University of Exeter, King’s College London and the University of Bergen are presenting two studies at the Alzheimer’s Association International Conference 2018 (AAIC) highlighting a significant increase in harmful side effects related to the use of commonly prescribed opioid painkillers in people with dementia, compared to those on a placebo. Researchers also identified a mechanism that may be causing the problem.In a randomized controlled trial of 162 Norwegian care home residents, the team found a significant rise in side effect such as personality changes, confusion and sedation, which can seriously impact people’s lives in dementia. The team is now calling for studies to examine appropriate dosing of painkillers such as buprenorphine for people with dementia.Around half of people with dementia who are living in care homes experience clinically significant pain. Previous research has recognized that pain is often under-diagnosed and poorly managed in people with dementia, impacting on quality of life.After paracetamol, opioid-based painkillers are often the next line of treatment for clinicians in people with dementia, and are prescribed to up to 40% of people with dementia living in care homes. They ease pain effectively, yet current prescribing guidance does not take into account the fact that people with dementia get effective pain relief from smaller doses than are commonly prescribed, and are particularly sensitive to adverse effects.The trial team, led by the University of Bergen, studied 162 people from 47 Norwegian care homes who had advanced dementia and significant depression. In those who were assigned buprenorphine as part of their treatment pathway, harmful side-effects more than tripled. The researchers also found that those taking buprenorphine were significantly less active during the day.Clive Ballard, Professor of Age-Related Diseases at the University of Exeter Medical School, said: “Pain is a symptom that can cause huge distress and it’s important that we can provide relief to people with dementia. Sadly at the moment we’re harming people when we’re trying to ease their pain. We urgently need more research in this area, and we must get this dosing right. We need to establish the best treatment pathway and examine appropriate dosing for people with dementia.”Related StoriesOU Health Sciences Center awarded federal grant to enhance dementia care across OklahomaAn active brain and body associated with reduced risk of dementiaMetformin use linked to lower risk of dementia in African Americans with type 2 diabetesImportantly, research led by Professor Ballard’s team and also presented at the conference gives insight into the mechanism of why people with dementia are more susceptible to opioid-based painkillers, suggesting they over-produce the body’s natural opioids.The study treating arthritis in Alzheimer’s mice found increased sensitivity to the opioid-based painkiller morphine in mice with Alzheimer’s disease compared to those without. Those with Alzheimer’s disease responded to a much lower dose to ease pain, and experienced more adverse effects when the dose was increased to a normal level. Looking into this further the study found that the Alzheimer’s mice produced more of the body’s natural endogenous opioids such as endorphins. The study, presented as a poster at AAIC, also concludes that dosing of opioid-based painkillers urgently needs to be reviewed in people with dementia to enable safe and effective treatment of pain, and prevent unnecessary harm and deaths.Two posters relating to this work are presented at AAIC. They are:A Randomized, Placebo-Controlled Trial to Investigate Safety in People with Dementia or Buprenorphine Transdermal System for Pain Management. Authors are Ane Erdal; Elisabeth Flo; Dag Aarsland; Clive Ballard, and Bettina Sandgathe Husebø. Tuesday July 24.Impaired chronic pain-like behavior and disruption of opioidergic system in TASTPM model of Alzheimer’s disease. Authors are Yahyah Aman, Thomas Pitcher, Clive Ballard, and Marzia Malcangio. Monday July 23.last_img read more